Mechanistic modeling of the SARS-CoV-2 disease map.

TitleMechanistic modeling of the SARS-CoV-2 disease map.
Publication TypeJournal Article
Year of Publication2021
AuthorsRian, K, Esteban-Medina, M, Hidalgo, MR, Cubuk, C, Falco, MM, Loucera, C, Gunyel, D, Ostaszewski, M, Peña-Chilet, M, Dopazo, J
JournalBioData Min
Date Published2021 Jan 21

Here we present a web interface that implements a comprehensive mechanistic model of the SARS-CoV-2 disease map. In this framework, the detailed activity of the human signaling circuits related to the viral infection, covering from the entry and replication mechanisms to the downstream consequences as inflammation and antigenic response, can be inferred from gene expression experiments. Moreover, the effect of potential interventions, such as knock-downs, or drug effects (currently the system models the effect of more than 8000 DrugBank drugs) can be studied. This freely available tool not only provides an unprecedentedly detailed view of the mechanisms of viral invasion and the consequences in the cell but has also the potential of becoming an invaluable asset in the search for efficient antiviral treatments.

Alternate JournalBioData Min
PubMed ID33478554
PubMed Central IDPMC7817765
Grant ListSAF2017-88908-R / / Ministerio de Economía y Competitividad /
PT17/0009/0006 / / Instituto de Salud Carlos III /
COV20/00788 / / Instituto de Salud Carlos III /
ACCI2018/29 / / Instituto de Salud Carlos III /
813533 / / FP7 People: Marie-Curie Actions /