LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus.

TitleLRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus.
Publication TypeJournal Article
Year of Publication2018
AuthorsCobo-Vuilleumier, N, Lorenzo, PI, Rodríguez, NGarcía, Gómez, Ide Gracia, Fuente-Martin, E, López-Noriega, L, Mellado-Gil, JManuel, Romero-Zerbo, S-Y, Baquié, M, Lachaud, CClaude, Stifter, K, Perdomo, G, Bugliani, M, De Tata, V, Bosco, D, Parnaud, G, Pozo, D, Hmadcha, A, Florido, JP, Toscano, MG, de Haan, P, Schoonjans, K, Palazón, LSánchez, Marchetti, P, Schirmbeck, R, Martín-Montalvo, A, Meda, P, Soria, B, Bermúdez-Silva, F-J, St-Onge, L, Gauthier, BR
JournalNat Commun
Date Published2018 04 16
KeywordsAnimals; Apoptosis; Cell Communication; Cell Survival; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Female; Gene Expression Regulation; Humans; Hypoglycemic Agents; Immunity, Innate; insulin; Insulin-Secreting Cells; Islets of Langerhans; Islets of Langerhans Transplantation; Macrophages; Male; Mice; Mice, Inbred C57BL; Phenalenes; Receptors, Cytoplasmic and Nuclear; Streptozocin; T-Lymphocytes, Regulatory; Transplantation, Heterologous

Type 1 diabetes mellitus (T1DM) is due to the selective destruction of islet beta cells by immune cells. Current therapies focused on repressing the immune attack or stimulating beta cell regeneration still have limited clinical efficacy. Therefore, it is timely to identify innovative targets to dampen the immune process, while promoting beta cell survival and function. Liver receptor homologue-1 (LRH-1) is a nuclear receptor that represses inflammation in digestive organs, and protects pancreatic islets against apoptosis. Here, we show that BL001, a small LRH-1 agonist, impedes hyperglycemia progression and the immune-dependent inflammation of pancreas in murine models of T1DM, and beta cell apoptosis in islets of type 2 diabetic patients, while increasing beta cell mass and insulin secretion. Thus, we suggest that LRH-1 agonism favors a dialogue between immune and islet cells, which could be druggable to protect against diabetes mellitus.

Alternate JournalNat Commun
PubMed ID29662071
PubMed Central IDPMC5902555