|Title||Expression profiling of T-cell lymphomas differentiates peripheral and lymphoblastic lymphomas and defines survival related genes.|
|Publication Type||Journal Article|
|Year of Publication||2004|
|Authors||Martinez-Delgado, B, Meléndez, B, Cuadros, M, Alvarez, J, Castrillo, JMaria, De La Parte, ARuiz, Mollejo, M, Bellas, C, Diaz, R, Lombardía, L, Al-Shahrour, F, Domínguez, O, Cascon, A, Robledo, M, Rivas, C, Benitez, J|
|Journal||Clinical cancer research : an official journal of the American Association for Cancer Research|
|Date Published||2004 Aug 1|
PURPOSE: T-Cell lymphomas constitute heterogeneous and aggressive tumors in which pathogenic alterations remain largely unknown. Expression profiling has demonstrated to be a useful tool for molecular classification of tumors. EXPERIMENTAL DESIGN: Using DNA microarrays (CNIO-OncoChip) containing 6386 cancer-related genes, we established the expression profiling of T-cell lymphomas and compared them to normal lymphocytes and lymph nodes. RESULTS: We found significant differences between the peripheral and lymphoblastic T-cell lymphomas, which include a deregulation of nuclear factor-kappaB signaling pathway. We also identify differentially expressed genes between peripheral T-cell lymphoma tumors and normal T lymphocytes or reactive lymph nodes, which could represent candidate tumor markers of these lymphomas. Additionally, a close relationship between genes associated to survival and those that differentiate among the stages of disease and responses to therapy was found. CONCLUSIONS: Our results reflect the value of gene expression profiling to gain insight about the molecular alterations involved in the pathogenesis of T-cell lymphomas.