|Title||Exploring the reasons for the large density of triplex-forming oligonucleotide target sequences in the human regulatory regions|
|Publication Type||Journal Article|
|Year of Publication||2006|
|Authors||Goni, JR, Vaquerizas, JM, Dopazo, J, Orozco, M|
|Keywords||Animals Base Sequence Computational Biology DNA/chemistry/*genetics/*metabolism Genome; Genetic/genetics Regulatory Sequences; Human/genetics Humans Mice Nucleic Acid Conformation Nucleotides/genetics Oligonucleotides/chemistry/*genetics/*metabolism Promoter Regions; Nucleic Acid/*genetics Transcription Factors/metabolism|
BACKGROUND: DNA duplex sequences that can be targets for triplex formation are highly over-represented in the human genome, especially in regulatory regions. RESULTS: Here we studied using bioinformatics tools several properties of triplex target sequences in an attempt to determine those that make these sequences so special in the genome. CONCLUSION: Our results strongly suggest that the unique physical properties of these sequences make them particularly suitable as "separators" between protein-recognition sites in the promoter region.
Goni, Josep Ramon Vaquerizas, Juan Manuel Dopazo, Joaquin Orozco, Modesto Research Support, Non-U.S. Gov’t England BMC genomics BMC Genomics. 2006 Mar 27;7:63.