Assessing the Impact of SARS-CoV-2 Lineages and Mutations on Patient Survival.

TitleAssessing the Impact of SARS-CoV-2 Lineages and Mutations on Patient Survival.
Publication TypeJournal Article
Year of Publication2022
AuthorsLoucera, C, Perez-Florido, J, Casimiro-Soriguer, CS, Ortuno, FM, Carmona, R, Bostelmann, G, L Martínez-González, J, Muñoyerro-Muñiz, D, Villegas, R, Rodríguez-Baño, J, Romero-Gómez, M, Lorusso, N, Garcia-León, J, Navarro-Marí, JM, Camacho-Martinez, P, Merino-Diaz, L, de Salazar, A, Viñuela, L, Lepe, JA, García, F, Dopazo, J
Date Published2022 Aug 27
KeywordsCOVID-19; Genome, Viral; Humans; mutation; Pandemics; Phylogeny; SARS-CoV-2

OBJECTIVES: More than two years into the COVID-19 pandemic, SARS-CoV-2 still remains a global public health problem. Successive waves of infection have produced new SARS-CoV-2 variants with new mutations for which the impact on COVID-19 severity and patient survival is uncertain.METHODS: A total of 764 SARS-CoV-2 genomes, sequenced from COVID-19 patients, hospitalized from 19th February 2020 to 30 April 2021, along with their clinical data, were used for survival analysis.RESULTS: A significant association of B.1.1.7, the alpha lineage, with patient mortality (log hazard ratio (LHR) = 0.51, C.I. = [0.14,0.88]) was found upon adjustment by all the covariates known to affect COVID-19 prognosis. Moreover, survival analysis of mutations in the SARS-CoV-2 genome revealed 27 of them were significantly associated with higher mortality of patients. Most of these mutations were located in the genes coding for the S, ORF8, and N proteins.CONCLUSIONS: This study illustrates how a combination of genomic and clinical data can provide solid evidence for the impact of viral lineage on patient survival.

Alternate JournalViruses
PubMed ID36146700
Grant ListPID2020-117979RB-I00 / / Ministerio de Ciencia e Innovación /
IMP/00019 / / Instituto de Salud Carlos III /
COVID-0012-2020 / / Consejería de Salud y Familias /
PS-2020-342 / / Consejería de Salud y Familias /
PAIDI2020- DOC_00350 / / Consejería de Salud y Familias /
871075 / / European Commission /