<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Menden, Michael P</style></author><author><style face="normal" font="default" size="100%">Wang, Dennis</style></author><author><style face="normal" font="default" size="100%">Mason, Mike J</style></author><author><style face="normal" font="default" size="100%">Szalai, Bence</style></author><author><style face="normal" font="default" size="100%">Bulusu, Krishna C</style></author><author><style face="normal" font="default" size="100%">Guan, Yuanfang</style></author><author><style face="normal" font="default" size="100%">Yu, Thomas</style></author><author><style face="normal" font="default" size="100%">Kang, Jaewoo</style></author><author><style face="normal" font="default" size="100%">Jeon, Minji</style></author><author><style face="normal" font="default" size="100%">Wolfinger, Russ</style></author><author><style face="normal" font="default" size="100%">Nguyen, Tin</style></author><author><style face="normal" font="default" size="100%">Zaslavskiy, Mikhail</style></author><author><style face="normal" font="default" size="100%">Jang, In Sock</style></author><author><style face="normal" font="default" size="100%">Ghazoui, Zara</style></author><author><style face="normal" font="default" size="100%">Ahsen, Mehmet Eren</style></author><author><style face="normal" font="default" size="100%">Vogel, Robert</style></author><author><style face="normal" font="default" size="100%">Neto, Elias Chaibub</style></author><author><style face="normal" font="default" size="100%">Norman, Thea</style></author><author><style face="normal" font="default" size="100%">Tang, Eric K Y</style></author><author><style face="normal" font="default" size="100%">Garnett, Mathew J</style></author><author><style face="normal" font="default" size="100%">Veroli, Giovanni Y Di</style></author><author><style face="normal" font="default" size="100%">Fawell, Stephen</style></author><author><style face="normal" font="default" size="100%">Stolovitzky, Gustavo</style></author><author><style face="normal" font="default" size="100%">Guinney, Justin</style></author><author><style face="normal" font="default" size="100%">Dry, Jonathan R</style></author><author><style face="normal" font="default" size="100%">Saez-Rodriguez, Julio</style></author></authors><translated-authors><author><style face="normal" font="default" size="100%">AstraZeneca-Sanger Drug Combination DREAM Consortium</style></author></translated-authors></contributors><titles><title><style face="normal" font="default" size="100%">Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen.</style></title><secondary-title><style face="normal" font="default" size="100%">Nat Commun</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Nat Commun</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ADAM17 Protein</style></keyword><keyword><style  face="normal" font="default" size="100%">Antineoplastic Combined Chemotherapy Protocols</style></keyword><keyword><style  face="normal" font="default" size="100%">Benchmarking</style></keyword><keyword><style  face="normal" font="default" size="100%">Biomarkers, Tumor</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell Line, Tumor</style></keyword><keyword><style  face="normal" font="default" size="100%">Computational Biology</style></keyword><keyword><style  face="normal" font="default" size="100%">Datasets as Topic</style></keyword><keyword><style  face="normal" font="default" size="100%">Drug Antagonism</style></keyword><keyword><style  face="normal" font="default" size="100%">Drug Resistance, Neoplasm</style></keyword><keyword><style  face="normal" font="default" size="100%">Drug Synergism</style></keyword><keyword><style  face="normal" font="default" size="100%">Genomics</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular Targeted Therapy</style></keyword><keyword><style  face="normal" font="default" size="100%">mutation</style></keyword><keyword><style  face="normal" font="default" size="100%">Neoplasms</style></keyword><keyword><style  face="normal" font="default" size="100%">pharmacogenetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Phosphatidylinositol 3-Kinases</style></keyword><keyword><style  face="normal" font="default" size="100%">Phosphoinositide-3 Kinase Inhibitors</style></keyword><keyword><style  face="normal" font="default" size="100%">Treatment Outcome</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2019 06 17</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">2674</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca's large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate computational strategies for predicting synergistic drug pairs and biomarkers. 160 teams participated to provide a comprehensive methodological development and benchmarking. Winning methods incorporate prior knowledge of drug-target interactions. Synergy is predicted with an accuracy matching biological replicates for &gt;60% of combinations. However, 20% of drug combinations are poorly predicted by all methods. Genomic rationale for synergy predictions are identified, including ADAM17 inhibitor antagonism when combined with PIK3CB/D inhibition contrasting to synergy when combined with other PI3K-pathway inhibitors in PIK3CA mutant cells.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><custom1><style face="normal" font="default" size="100%">https://www.ncbi.nlm.nih.gov/pubmed/31209238?dopt=Abstract</style></custom1></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Eduati, Federica</style></author><author><style face="normal" font="default" size="100%">Mangravite, Lara M</style></author><author><style face="normal" font="default" size="100%">Wang, Tao</style></author><author><style face="normal" font="default" size="100%">Tang, Hao</style></author><author><style face="normal" font="default" size="100%">Bare, J Christopher</style></author><author><style face="normal" font="default" size="100%">Huang, Ruili</style></author><author><style face="normal" font="default" size="100%">Norman, Thea</style></author><author><style face="normal" font="default" size="100%">Kellen, Mike</style></author><author><style face="normal" font="default" size="100%">Menden, Michael P</style></author><author><style face="normal" font="default" size="100%">Yang, Jichen</style></author><author><style face="normal" font="default" size="100%">Zhan, Xiaowei</style></author><author><style face="normal" font="default" size="100%">Zhong, Rui</style></author><author><style face="normal" font="default" size="100%">Xiao, Guanghua</style></author><author><style face="normal" font="default" size="100%">Xia, Menghang</style></author><author><style face="normal" font="default" size="100%">Abdo, Nour</style></author><author><style face="normal" font="default" size="100%">Kosyk, Oksana</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Prediction of human population responses to toxic compounds by a collaborative competition.</style></title><secondary-title><style face="normal" font="default" size="100%">Nature biotechnology</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2015 Aug 10</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.nature.com/nbt/journal/vaop/ncurrent/full/nbt.3299.html</style></url></web-urls></urls><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">The ability to computationally predict the effects of toxic compounds on humans could help address the deficiencies of current chemical safety testing. Here, we report the results from a community-based DREAM challenge to predict toxicities of environmental compounds with potential adverse health effects for human populations. We measured the cytotoxicity of 156 compounds in 884 lymphoblastoid cell lines for which genotype and transcriptional data are available as part of the Tox21 1000 Genomes Project. The challenge participants developed algorithms to predict interindividual variability of toxic response from genomic profiles and population-level cytotoxicity data from structural attributes of the compounds. 179 submitted predictions were evaluated against an experimental data set to which participants were blinded. Individual cytotoxicity predictions were better than random, with modest correlations (Pearson’s r &lt; 0.28), consistent with complex trait genomic prediction. In contrast, predictions of population-level response to different compounds were higher (r &lt; 0.66). The results highlight the possibility of predicting health risks associated with unknown compounds, although risk estimation accuracy remains suboptimal.</style></abstract></record></records></xml>