<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Cruz, Raquel</style></author><author><style face="normal" font="default" size="100%">Almeida, Silvia Diz-de</style></author><author><style face="normal" font="default" size="100%">Heredia, Miguel López</style></author><author><style face="normal" font="default" size="100%">Quintela, Inés</style></author><author><style face="normal" font="default" size="100%">Ceballos, Francisco C</style></author><author><style face="normal" font="default" size="100%">Pita, Guillermo</style></author><author><style face="normal" font="default" size="100%">Lorenzo-Salazar, José M</style></author><author><style face="normal" font="default" size="100%">González-Montelongo, Rafaela</style></author><author><style face="normal" font="default" size="100%">Gago-Domínguez, Manuela</style></author><author><style face="normal" font="default" size="100%">Porras, Marta Sevilla</style></author><author><style face="normal" font="default" size="100%">Castaño, Jair Antonio Tenorio</style></author><author><style face="normal" font="default" size="100%">Nevado, Julián</style></author><author><style face="normal" font="default" size="100%">Aguado, Jose María</style></author><author><style face="normal" font="default" size="100%">Aguilar, Carlos</style></author><author><style face="normal" font="default" size="100%">Aguilera-Albesa, Sergio</style></author><author><style face="normal" font="default" size="100%">Almadana, Virginia</style></author><author><style face="normal" font="default" size="100%">Almoguera, Berta</style></author><author><style face="normal" font="default" size="100%">Alvarez, Nuria</style></author><author><style face="normal" font="default" size="100%">Andreu-Bernabeu, Álvaro</style></author><author><style face="normal" font="default" size="100%">Arana-Arri, Eunate</style></author><author><style face="normal" font="default" size="100%">Arango, Celso</style></author><author><style face="normal" font="default" size="100%">Arranz, María J</style></author><author><style face="normal" font="default" size="100%">Artiga, Maria-Jesus</style></author><author><style face="normal" font="default" size="100%">Baptista-Rosas, Raúl C</style></author><author><style face="normal" font="default" size="100%">Barreda-Sánchez, María</style></author><author><style face="normal" font="default" size="100%">Belhassen-Garcia, Moncef</style></author><author><style face="normal" font="default" size="100%">Bezerra, Joao F</style></author><author><style face="normal" font="default" size="100%">Bezerra, Marcos A C</style></author><author><style face="normal" font="default" size="100%">Boix-Palop, Lucía</style></author><author><style face="normal" font="default" size="100%">Brión, Maria</style></author><author><style face="normal" font="default" size="100%">Brugada, Ramón</style></author><author><style face="normal" font="default" size="100%">Bustos, Matilde</style></author><author><style face="normal" font="default" size="100%">Calderón, Enrique J</style></author><author><style face="normal" font="default" size="100%">Carbonell, Cristina</style></author><author><style face="normal" font="default" size="100%">Castano, Luis</style></author><author><style face="normal" font="default" size="100%">Castelao, Jose E</style></author><author><style face="normal" font="default" size="100%">Conde-Vicente, Rosa</style></author><author><style face="normal" font="default" size="100%">Cordero-Lorenzana, M Lourdes</style></author><author><style face="normal" font="default" size="100%">Cortes-Sanchez, Jose L</style></author><author><style face="normal" font="default" size="100%">Corton, Marta</style></author><author><style face="normal" font="default" size="100%">Darnaude, M Teresa</style></author><author><style face="normal" font="default" size="100%">De Martino-Rodríguez, Alba</style></author><author><style face="normal" font="default" size="100%">Campo-Pérez, Victor</style></author><author><style face="normal" font="default" size="100%">Bustamante, Aranzazu Diaz</style></author><author><style face="normal" font="default" size="100%">Domínguez-Garrido, Elena</style></author><author><style face="normal" font="default" size="100%">Luchessi, André D</style></author><author><style face="normal" font="default" size="100%">Eirós, Rocío</style></author><author><style face="normal" font="default" size="100%">Sanabria, Gladys Mercedes Estigarribia</style></author><author><style face="normal" font="default" size="100%">Fariñas, María Carmen</style></author><author><style face="normal" font="default" size="100%">Fernández-Robelo, Uxía</style></author><author><style face="normal" font="default" size="100%">Fernández-Rodríguez, Amanda</style></author><author><style face="normal" font="default" size="100%">Fernández-Villa, Tania</style></author><author><style face="normal" font="default" size="100%">Gil-Fournier, Belén</style></author><author><style face="normal" font="default" size="100%">Gómez-Arrue, Javier</style></author><author><style face="normal" font="default" size="100%">Álvarez, Beatriz González</style></author><author><style face="normal" font="default" size="100%">Quirós, Fernan Gonzalez Bernaldo</style></author><author><style face="normal" font="default" size="100%">González-Peñas, Javier</style></author><author><style face="normal" font="default" size="100%">Gutiérrez-Bautista, Juan F</style></author><author><style face="normal" font="default" size="100%">Herrero, María José</style></author><author><style face="normal" font="default" size="100%">Herrero-Gonzalez, Antonio</style></author><author><style face="normal" font="default" size="100%">Jimenez-Sousa, María A</style></author><author><style face="normal" font="default" size="100%">Lattig, María Claudia</style></author><author><style face="normal" font="default" size="100%">Borja, Anabel Liger</style></author><author><style face="normal" font="default" size="100%">Lopez-Rodriguez, Rosario</style></author><author><style face="normal" font="default" size="100%">Mancebo, Esther</style></author><author><style face="normal" font="default" size="100%">Martín-López, Caridad</style></author><author><style face="normal" font="default" size="100%">Martín, Vicente</style></author><author><style face="normal" font="default" size="100%">Martinez-Nieto, Oscar</style></author><author><style face="normal" font="default" size="100%">Martinez-Lopez, Iciar</style></author><author><style face="normal" font="default" size="100%">Martinez-Resendez, Michel F</style></author><author><style face="normal" font="default" size="100%">Martinez-Perez, Ángel</style></author><author><style face="normal" font="default" size="100%">Mazzeu, Juliana A</style></author><author><style face="normal" font="default" size="100%">Macías, Eleuterio Merayo</style></author><author><style face="normal" font="default" size="100%">Minguez, Pablo</style></author><author><style face="normal" font="default" size="100%">Cuerda, Victor Moreno</style></author><author><style face="normal" font="default" size="100%">Silbiger, Vivian N</style></author><author><style face="normal" font="default" size="100%">Oliveira, Silviene F</style></author><author><style face="normal" font="default" size="100%">Ortega-Paino, Eva</style></author><author><style face="normal" font="default" size="100%">Parellada, Mara</style></author><author><style face="normal" font="default" size="100%">Paz-Artal, Estela</style></author><author><style face="normal" font="default" size="100%">Santos, Ney P C</style></author><author><style face="normal" font="default" size="100%">Pérez-Matute, Patricia</style></author><author><style face="normal" font="default" size="100%">Perez, Patricia</style></author><author><style face="normal" font="default" size="100%">Pérez-Tomás, M Elena</style></author><author><style face="normal" font="default" size="100%">Perucho, Teresa</style></author><author><style face="normal" font="default" size="100%">Pinsach-Abuin, Mel Lina</style></author><author><style face="normal" font="default" size="100%">Pompa-Mera, Ericka N</style></author><author><style face="normal" font="default" size="100%">Porras-Hurtado, Gloria L</style></author><author><style face="normal" font="default" size="100%">Pujol, Aurora</style></author><author><style face="normal" font="default" size="100%">León, Soraya Ramiro</style></author><author><style face="normal" font="default" size="100%">Resino, Salvador</style></author><author><style face="normal" font="default" size="100%">Fernandes, Marianne R</style></author><author><style face="normal" font="default" size="100%">Rodríguez-Ruiz, Emilio</style></author><author><style face="normal" font="default" size="100%">Rodriguez-Artalejo, Fernando</style></author><author><style face="normal" font="default" size="100%">Rodriguez-Garcia, José A</style></author><author><style face="normal" font="default" size="100%">Ruiz-Cabello, Francisco</style></author><author><style face="normal" font="default" size="100%">Ruiz-Hornillos, Javier</style></author><author><style face="normal" font="default" size="100%">Ryan, Pablo</style></author><author><style face="normal" font="default" size="100%">Soria, José Manuel</style></author><author><style face="normal" font="default" size="100%">Souto, Juan Carlos</style></author><author><style face="normal" font="default" size="100%">Tamayo, Eduardo</style></author><author><style face="normal" font="default" size="100%">Tamayo-Velasco, Alvaro</style></author><author><style face="normal" font="default" size="100%">Taracido-Fernandez, Juan Carlos</style></author><author><style face="normal" font="default" size="100%">Teper, Alejandro</style></author><author><style face="normal" font="default" size="100%">Torres-Tobar, Lilian</style></author><author><style face="normal" font="default" size="100%">Urioste, Miguel</style></author><author><style face="normal" font="default" size="100%">Valencia-Ramos, Juan</style></author><author><style face="normal" font="default" size="100%">Yáñez, Zuleima</style></author><author><style face="normal" font="default" size="100%">Zarate, Ruth</style></author><author><style face="normal" font="default" size="100%">Nakanishi, Tomoko</style></author><author><style face="normal" font="default" size="100%">Pigazzini, Sara</style></author><author><style face="normal" font="default" size="100%">Degenhardt, Frauke</style></author><author><style face="normal" font="default" size="100%">Butler-Laporte, Guillaume</style></author><author><style face="normal" font="default" size="100%">Maya-Miles, Douglas</style></author><author><style face="normal" font="default" size="100%">Bujanda, Luis</style></author><author><style face="normal" font="default" size="100%">Bouysran, Youssef</style></author><author><style face="normal" font="default" size="100%">Palom, Adriana</style></author><author><style face="normal" font="default" size="100%">Ellinghaus, David</style></author><author><style face="normal" font="default" size="100%">Martínez-Bueno, Manuel</style></author><author><style face="normal" font="default" size="100%">Rolker, Selina</style></author><author><style face="normal" font="default" size="100%">Amitrano, Sara</style></author><author><style face="normal" font="default" size="100%">Roade, Luisa</style></author><author><style face="normal" font="default" size="100%">Fava, Francesca</style></author><author><style face="normal" font="default" size="100%">Spinner, Christoph D</style></author><author><style face="normal" font="default" size="100%">Prati, Daniele</style></author><author><style face="normal" font="default" size="100%">Bernardo, David</style></author><author><style face="normal" font="default" size="100%">García, Federico</style></author><author><style face="normal" font="default" size="100%">Darcis, Gilles</style></author><author><style face="normal" font="default" size="100%">Fernández-Cadenas, Israel</style></author><author><style face="normal" font="default" size="100%">Holter, Jan Cato</style></author><author><style face="normal" font="default" size="100%">Banales, Jesus M</style></author><author><style face="normal" font="default" size="100%">Frithiof, Robert</style></author><author><style face="normal" font="default" size="100%">Duga, Stefano</style></author><author><style face="normal" font="default" size="100%">Asselta, Rosanna</style></author><author><style face="normal" font="default" size="100%">Pereira, Alexandre C</style></author><author><style face="normal" font="default" size="100%">Romero-Gómez, Manuel</style></author><author><style face="normal" font="default" size="100%">Nafría-Jiménez, Beatriz</style></author><author><style face="normal" font="default" size="100%">Hov, Johannes R</style></author><author><style face="normal" font="default" size="100%">Migeotte, Isabelle</style></author><author><style face="normal" font="default" size="100%">Renieri, Alessandra</style></author><author><style face="normal" font="default" size="100%">Planas, Anna M</style></author><author><style face="normal" font="default" size="100%">Ludwig, Kerstin U</style></author><author><style face="normal" font="default" size="100%">Buti, Maria</style></author><author><style face="normal" font="default" size="100%">Rahmouni, Souad</style></author><author><style face="normal" font="default" size="100%">Alarcón-Riquelme, Marta E</style></author><author><style face="normal" font="default" size="100%">Schulte, Eva C</style></author><author><style face="normal" font="default" size="100%">Franke, Andre</style></author><author><style face="normal" font="default" size="100%">Karlsen, Tom H</style></author><author><style face="normal" font="default" size="100%">Valenti, Luca</style></author><author><style face="normal" font="default" size="100%">Zeberg, Hugo</style></author><author><style face="normal" font="default" size="100%">Richards, Brent</style></author><author><style face="normal" font="default" size="100%">Ganna, Andrea</style></author><author><style face="normal" font="default" size="100%">Boada, Mercè</style></author><author><style face="normal" font="default" size="100%">Rojas, Itziar</style></author><author><style face="normal" font="default" size="100%">Ruiz, Agustín</style></author><author><style face="normal" font="default" size="100%">Sánchez, Pascual</style></author><author><style face="normal" font="default" size="100%">Real, Luis Miguel</style></author><author><style face="normal" font="default" size="100%">Guillén-Navarro, Encarna</style></author><author><style face="normal" font="default" size="100%">Ayuso, Carmen</style></author><author><style face="normal" font="default" size="100%">González-Neira, Anna</style></author><author><style face="normal" font="default" size="100%">Riancho, José A</style></author><author><style face="normal" font="default" size="100%">Rojas-Martinez, Augusto</style></author><author><style face="normal" font="default" size="100%">Flores, Carlos</style></author><author><style face="normal" font="default" size="100%">Lapunzina, Pablo</style></author><author><style face="normal" font="default" size="100%">Carracedo, Ángel</style></author></authors><translated-authors><author><style face="normal" font="default" size="100%">SCOURGE Cohort Group</style></author><author><style face="normal" font="default" size="100%">HOSTAGE Cohort Group</style></author><author><style face="normal" font="default" size="100%">GRA@CE Cohort Group</style></author></translated-authors></contributors><titles><title><style face="normal" font="default" size="100%">Novel genes and sex differences in COVID-19 severity.</style></title><secondary-title><style face="normal" font="default" size="100%">Hum Mol Genet</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Hum Mol Genet</style></alt-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2022 Jun 16</style></date></pub-dates></dates><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Here we describe the results of a genome-wide study conducted in 11 939 COVID-19 positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (p &lt; 5x10-8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (p = 1.3x10-22 and p = 8.1x10-12, respectively), and for variants in 9q21.32 near TLE1 only among females (p = 4.4x10-8). In a second phase, results were combined with an independent Spanish cohort (1598 COVID-19 cases and 1068 population controls), revealing in the overall analysis two novel risk loci in 9p13.3 and 19q13.12, with fine-mapping prioritized variants functionally associated with AQP3 (p = 2.7x10-8) and ARHGAP33 (p = 1.3x10-8), respectively. The meta-analysis of both phases with four European studies stratified by sex from the Host Genetics Initiative confirmed the association of the 3p21.31 and 21q22.11 loci predominantly in males and replicated a recently reported variant in 11p13 (ELF5, p = 4.1x10-8). Six of the COVID-19 HGI discovered loci were replicated and an HGI-based genetic risk score predicted the severity strata in SCOURGE. We also found more SNP-heritability and larger heritability differences by age (&lt;60 or ≥ 60 years) among males than among females. Parallel genome-wide screening of inbreeding depression in SCOURGE also showed an effect of homozygosity in COVID-19 hospitalization and severity and this effect was stronger among older males. In summary, new candidate genes for COVID-19 severity and evidence supporting genetic disparities among sexes are provided.&lt;/p&gt;</style></abstract></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Martorell-Marugán, Jordi</style></author><author><style face="normal" font="default" size="100%">López-Domínguez, Raúl</style></author><author><style face="normal" font="default" size="100%">García-Moreno, Adrián</style></author><author><style face="normal" font="default" size="100%">Toro-Domínguez, Daniel</style></author><author><style face="normal" font="default" size="100%">Villatoro-García, Juan Antonio</style></author><author><style face="normal" font="default" size="100%">Barturen, Guillermo</style></author><author><style face="normal" font="default" size="100%">Martín-Gómez, Adoración</style></author><author><style face="normal" font="default" size="100%">Troule, Kevin</style></author><author><style face="normal" font="default" size="100%">Gómez-López, Gonzalo</style></author><author><style face="normal" font="default" size="100%">Al-Shahrour, Fátima</style></author><author><style face="normal" font="default" size="100%">González-Rumayor, Víctor</style></author><author><style face="normal" font="default" size="100%">Peña-Chilet, Maria</style></author><author><style face="normal" font="default" size="100%">Dopazo, Joaquin</style></author><author><style face="normal" font="default" size="100%">Saez-Rodriguez, Julio</style></author><author><style face="normal" font="default" size="100%">Alarcón-Riquelme, Marta E</style></author><author><style face="normal" font="default" size="100%">Carmona-Sáez, Pedro</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A comprehensive database for integrated analysis of omics data in autoimmune diseases.</style></title><secondary-title><style face="normal" font="default" size="100%">BMC Bioinformatics</style></secondary-title><alt-title><style face="normal" font="default" size="100%">BMC Bioinformatics</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Autoimmune Diseases</style></keyword><keyword><style  face="normal" font="default" size="100%">Computational Biology</style></keyword><keyword><style  face="normal" font="default" size="100%">Databases, Factual</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2021 Jun 24</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">22</style></volume><pages><style face="normal" font="default" size="100%">343</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;b&gt;BACKGROUND: &lt;/b&gt;Autoimmune diseases are heterogeneous pathologies with difficult diagnosis and few therapeutic options. In the last decade, several omics studies have provided significant insights into the molecular mechanisms of these diseases. Nevertheless, data from different cohorts and pathologies are stored independently in public repositories and a unified resource is imperative to assist researchers in this field.&lt;/p&gt;&lt;p&gt;&lt;b&gt;RESULTS: &lt;/b&gt;Here, we present Autoimmune Diseases Explorer ( https://adex.genyo.es ), a database that integrates 82 curated transcriptomics and methylation studies covering 5609 samples for some of the most common autoimmune diseases. The database provides, in an easy-to-use environment, advanced data analysis and statistical methods for exploring omics datasets, including meta-analysis, differential expression or pathway analysis.&lt;/p&gt;&lt;p&gt;&lt;b&gt;CONCLUSIONS: &lt;/b&gt;This is the first omics database focused on autoimmune diseases. This resource incorporates homogeneously processed data to facilitate integrative analyses among studies.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><custom1><style face="normal" font="default" size="100%">https://www.ncbi.nlm.nih.gov/pubmed/34167460?dopt=Abstract</style></custom1></record></records></xml>