<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gabaldón, T.</style></author><author><style face="normal" font="default" size="100%">M. A. Huynen</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Lineage-specific gene loss following mitochondrial endosymbiosis and its potential for function prediction in eukaryotes</style></title><secondary-title><style face="normal" font="default" size="100%">Bioinformatics</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Animals Chromosome Mapping/*methods DNA</style></keyword><keyword><style  face="normal" font="default" size="100%">Mitochondrial/*genetics *Evolution</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular *Gene Deletion Genetic Variation/genetics Humans Linkage Disequilibrium/*genetics Mitochondrial Proteins/*genetics Sequence Homology</style></keyword><keyword><style  face="normal" font="default" size="100%">Nucleic Acid Species Specificity Symbiosis/*genetics</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2005</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=16204094</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">21 Suppl 2</style></volume><pages><style face="normal" font="default" size="100%">ii144-50</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">MOTIVATION: The endosymbiotic origin of mitochondria has resulted in a massive horizontal transfer of genetic material from an alpha-proteobacterium to the early eukaryotes. Using large-scale phylogenetic analysis we have previously identified 630 orthologous groups of proteins derived from this event. Here we show that this proto-mitochondrial protein set has undergone extensive lineage-specific gene loss in the eukaryotes, with an average of three losses per orthologous group in a phylogeny of nine species. This gene loss has resulted in a high variability of the alphaproteobacterial-derived gene content of present-day eukaryotic genomes that might reflect functional adaptation to different environments. Proteins functioning in the same biochemical pathway tend to have a similar history of gene loss events, and we use this property to predict functional interactions among proteins in our set.</style></abstract><notes><style face="normal" font="default" size="100%">Gabaldon, Toni Huynen, Martijn A Research Support, Non-U.S. Gov’t England Bioinformatics (Oxford, England) Bioinformatics. 2005 Sep 1;21 Suppl 2:ii144-50.</style></notes></record></records></xml>