TY - JOUR T1 - Recent human evolution has shaped geographical differences in susceptibility to disease. JF - BMC genomics Y1 - 2011 A1 - Marigorta, Urko M A1 - Lao, Oscar A1 - Casals, Ferran A1 - Calafell, Francesc A1 - Morcillo-Suarez, Carlos A1 - Faria, Rui A1 - Bosch, Elena A1 - Serra, François A1 - Bertranpetit, Jaume A1 - Dopazo, Hernán A1 - Navarro, Arcadi AB -

Searching for associations between genetic variants and complex diseases has been a very active area of research for over two decades. More than 51,000 potential associations have been studied and published, a figure that keeps increasing, especially with the recent explosion of array-based Genome-Wide Association Studies. Even if the number of true associations described so far is high, many of the putative risk variants detected so far have failed to be consistently replicated and are widely considered false positives. Here, we focus on the world-wide patterns of replicability of published association studies.

VL - 12 ER -