TY - JOUR T1 - Genomics and transcriptomics in drug discovery. JF - Drug discovery today Y1 - 2014 A1 - Dopazo, Joaquin KW - adverse effects KW - Drug discovery KW - drug repositioning KW - metagenomics KW - modeling KW - network analysis KW - pathway analysis AB - The popularization of genomic high-throughput technologies is causing a revolution in biomedical research and, particularly, is transforming the field of drug discovery. Systems biology offers a framework to understand the extensive human genetic heterogeneity revealed by genomic sequencing in the context of the network of functional, regulatory and physical protein-drug interactions. Thus, approaches to find biomarkers and therapeutic targets will have to take into account the complex system nature of the relationships of the proteins with the disease. Pharmaceutical companies will have to reorient their drug discovery strategies considering the human genetic heterogeneity. Consequently, modeling and computational data analysis will have an increasingly important role in drug discovery. VL - 19 UR - http://www.ncbi.nlm.nih.gov/pubmed/23773860 ER -