TY - JOUR T1 - myKaryoView: a light-weight client for visualization of genomic data. JF - PLoS One Y1 - 2011 A1 - Jimenez, Rafael C A1 - Salazar, Gustavo A A1 - Gel, Bernat A1 - Dopazo, Joaquin A1 - Mulder, Nicola A1 - Corpas, Manuel KW - Computer Graphics KW - Databases, Genetic KW - Genomics KW - Internet KW - Molecular Sequence Annotation KW - User-Computer Interface AB -

The Distributed Annotation System (DAS) is a protocol for easy sharing and integration of biological annotations. In order to visualize feature annotations in a genomic context a client is required. Here we present myKaryoView, a simple light-weight DAS tool for visualization of genomic annotation. myKaryoView has been specifically configured to help analyse data derived from personal genomics, although it can also be used as a generic genome browser visualization. Several well-known data sources are provided to facilitate comparison of known genes and normal variation regions. The navigation experience is enhanced by simultaneous rendering of different levels of detail across chromosomes. A simple interface is provided to allow searches for any SNP, gene or chromosomal region. User-defined DAS data sources may also be added when querying the system. We demonstrate myKaryoView capabilities for adding user-defined sources with a set of genetic profiles of family-related individuals downloaded directly from 23andMe. myKaryoView is a web tool for visualization of genomic data specifically designed for direct-to-consumer genomic data that uses publicly available data distributed throughout the Internet. It does not require data to be held locally and it is capable of rendering any feature as long as it conforms to DAS specifications. Configuration and addition of sources to myKaryoView can be done through the interface. Here we show a proof of principle of myKaryoView's ability to display personal genomics data with 23andMe genome data sources. The tool is available at: http://mykaryoview.com.

VL - 6 IS - 10 U1 - https://www.ncbi.nlm.nih.gov/pubmed/22046276?dopt=Abstract ER -