02505nas a2200253   4500008004100000022001400041245014000055210006900195260000900264300001100273490000600284520158800290100002601878700003001904700002801934700002801962700001901990700002902009700002102038700002502059700002102084700002002105856012602125       2013                        eng d  a1932-620300aMaslinic Acid-Enriched Diet Decreases Intestinal Tumorigenesis in Apc(Min/+) Mice through Transcriptomic and Metabolomic Reprogramming.0 aMaslinic AcidEnriched Diet Decreases Intestinal Tumorigenesis in  c2013  ae593920 v83 aChemoprevention is a pragmatic approach to reduce the risk of colorectal cancer, one of the leading causes of cancer-related death in western countries. In this regard, maslinic acid (MA), a pentacyclic triterpene extracted from wax-like coatings of olives, is known to inhibit proliferation and induce apoptosis in colon cancer cell lines without affecting normal intestinal cells. The present study evaluated the chemopreventive efficacy and associated mechanisms of maslinic acid treatment on spontaneous intestinal tumorigenesis in Apc(Min/+) mice. Twenty-two mice were randomized into 2 groups: control group and MA group, fed with a maslinic acid-supplemented diet for six weeks. MA treatment reduced total intestinal polyp formation by 45% (P<0.01). Putative molecular mechanisms associated with suppressing intestinal polyposis in Apc(Min/+) mice were investigated by comparing microarray expression profiles of MA-treated and control mice and by analyzing the serum metabolic profile using NMR techniques. The different expression phenotype induced by MA suggested that it exerts its chemopreventive action mainly by inhibiting cell-survival signaling and inflammation. These changes eventually induce G1-phase cell cycle arrest and apoptosis. Moreover, the metabolic changes induced by MA treatment were associated with a protective profile against intestinal tumorigenesis. These results show the efficacy and underlying mechanisms of MA against intestinal tumor development in the Apc(Min/+) mice model, suggesting its chemopreventive potential against colorectal cancer.1 aSánchez-Tena, Susana1 aReyes-Zurita, Fernando, J1 aDíaz-Moralli, Santiago1 aVinardell, Maria, Pilar1 aReed, Michelle1 aGarcia-Garcia, Francisco1 aDopazo, Joaquín1 aLupiáñez, José, A1 aGünther, Ulrich1 aCascante, Marta  uhttps://www.clinbioinfosspa.es/content/maslinic-acid-enriched-diet-decreases-intestinal-tumorigenesis-apcmin-mice-through