02746nas a2200253   4500008004100000022001400041245011600055210006900171260001600240490000700256520183900263100002002102700002402122700002202146700002002168700002802188700002702216700002602243700002902269700002002298700001802318700002602336856013002362       2021                        eng d  a2075-442600aImplementing Personalized Medicine in COVID-19 in Andalusia: An Opportunity to Transform the Healthcare System.0 aImplementing Personalized Medicine in COVID19 in Andalusia An Op  c2021 May 260 v113 a<p>The COVID-19 pandemic represents an unprecedented opportunity to exploit the advantages of personalized medicine for the prevention, diagnosis, treatment, surveillance and management of a new challenge in public health. COVID-19 infection is highly variable, ranging from asymptomatic infections to severe, life-threatening manifestations. Personalized medicine can play a key role in elucidating individual susceptibility to the infection as well as inter-individual variability in clinical course, prognosis and response to treatment. Integrating personalized medicine into clinical practice can also transform health care by enabling the design of preventive and therapeutic strategies tailored to individual profiles, improving the detection of outbreaks or defining transmission patterns at an increasingly local level. SARS-CoV2 genome sequencing, together with the assessment of specific patient genetic variants, will support clinical decision-makers and ultimately better ways to fight this disease. Additionally, it would facilitate a better stratification and selection of patients for clinical trials, thus increasing the likelihood of obtaining positive results. Lastly, defining a national strategy to implement in clinical practice all available tools of personalized medicine in COVID-19 could be challenging but linked to a positive transformation of the health care system. In this review, we provide an update of the achievements, promises, and challenges of personalized medicine in the fight against COVID-19 from susceptibility to natural history and response to therapy, as well as from surveillance to control measures and vaccination. We also discuss strategies to facilitate the adoption of this new paradigm for medical and public health measures during and after the pandemic in health care systems.</p>1 aDopazo, Joaquin1 aMaya-Miles, Douglas1 aGarcía, Federico1 aLorusso, Nicola1 aCalleja, Miguel, Ángel1 aPareja, María, Jesús1 aLópez-Miranda, José1 aRodríguez-Baño, Jesús1 aPadillo, Javier1 aTúnez, Isaac1 aRomero-Gómez, Manuel  uhttps://www.clinbioinfosspa.es/content/implementing-personalized-medicine-covid-19-andalusia-opportunity-transform-healthcare