02759nas a2200265   4500008004100000022001400041245011700055210006900172260001600241520176800257100003002025700002102055700002002076700002302096700002302119700001902142700002602161700002602187700003302213700002302246700002002269700003602289700002202325856014602347       2024                        eng d  a1476-557800aMutational landscape of risk variants in comorbid depression and obesity: a next-generation sequencing approach.0 aMutational landscape of risk variants in comorbid depression and  c2024 May 283 a<p>Major depression (MD) and obesity are complex genetic disorders that are frequently comorbid. However, the study of both diseases concurrently remains poorly addressed and therefore the underlying genetic mechanisms involved in this comorbidity remain largely unknown. Here we examine the contribution of common and rare variants to this comorbidity through a next-generation sequencing (NGS) approach. Specific genomic regions of interest in MD and obesity were sequenced in a group of 654 individuals from the PISMA-ep epidemiological study. We obtained variants across the entire frequency spectrum and assessed their association with comorbid MD and obesity, both at variant and gene levels. We identified 55 independent common variants and a burden of rare variants in 4 genes (PARK2, FGF21, HIST1H3D and RSRC1) associated with the comorbid phenotype. Follow-up analyses revealed significantly enriched gene-sets associated with biological processes and pathways involved in metabolic dysregulation, hormone signaling and cell cycle regulation. Our results suggest that, while risk variants specific to the comorbid phenotype have been identified, the genes functionally impacted by the risk variants share cell biological processes and signaling pathways with MD and obesity phenotypes separately. To the best of our knowledge, this is the first study involving a targeted sequencing approach toward the study of the comorbid MD and obesity. The framework presented here allowed a deep characterization of the genetics of the co-occurring MD and obesity, revealing insights into the mutational and functional profile that underlies this comorbidity and contributing to a better understanding of the relationship between these two disabling disorders.</p>1 aPérez-Gutiérrez, Ana, M1 aCarmona, Rosario1 aLoucera, Carlos1 aCervilla, Jorge, A1 aGutiérrez, Blanca1 aMolina, Esther1 aLópez-López, Daniel1 aPerez-Florido, Javier1 aZarza-Rebollo, Juan, Antonio1 aLópez-Isac, Elena1 aDopazo, Joaquin1 aMartinez-Gonzalez, Luis, Javier1 aRivera, Margarita  uhttps://www.clinbioinfosspa.es/content/mutational-landscape-risk-variants-comorbid-depression-and-obesity-next-generation-sequencing-approach00782nas a2200229   4500008004100000245009000041210006900131260001600200300000800216490000700224100003400231700002600265700003000291700002600321700002700347700002000374700003600394700002800430700002000458700002900478856004500507       2021                        eng d00aPhylogenetic Analysis of the 2020 West Nile Virus (WNV) Outbreak in Andalusia (Spain)0 aPhylogenetic Analysis of the 2020 West Nile Virus WNV Outbreak i  cJan-05-2021  a8360 v131 aCasimiro-Soriguer, Carlos, S.1 aPerez-Florido, Javier1 aFernandez-Rueda, Jose, L.1 aPedrosa-Corral, Irene1 aGuillot-Sulay, Vicente1 aLorusso, Nicola1 aMartinez-Gonzalez, Luis, Javier1 aNavarro-Marí, Jose, M.1 aDopazo, Joaquin1 aSanbonmatsu-Gámez, Sara  uhttps://www.mdpi.com/1999-4915/13/5/836 