01901nas a2200241   4500008004100000022001400041245008000055210006900135260000900204300000800213490000700221520123600228653001101464653000801475653001301483653000801496100002301504700002301527700001901550700002001569700002001589856005001609       2016                        eng d  a1471-210500aHPG pore: an efficient and scalable framework for nanopore sequencing data.0 aHPG pore an efficient and scalable framework for nanopore sequen  c2016  a1070 v173 aBACKGROUND: The use of nanopore technologies is expected to spread in the future because they are portable and can sequence long fragments of DNA molecules without prior amplification. The first nanopore sequencer available, the MinION™ from Oxford Nanopore Technologies, is a USB-connected, portable device that allows real-time DNA analysis. In addition, other new instruments are expected to be released soon, which promise to outperform the current short-read technologies in terms of throughput. Despite the flood of data expected from this technology, the data analysis solutions currently available are only designed to manage small projects and are not scalable. RESULTS: Here we present HPG Pore, a toolkit for exploring and analysing nanopore sequencing data. HPG Pore can run on both individual computers and in the Hadoop distributed computing framework, which allows easy scale-up to manage the large amounts of data expected to result from extensive use of nanopore technologies in the future. CONCLUSIONS: HPG Pore allows for virtually unlimited sequencing data scalability, thus guaranteeing its continued management in near future scenarios. HPG Pore is available in GitHub at http://github.com/opencb/hpg-pore .10ahadoop10aHPC10ananopore10aNGS1 aTárraga, Joaquín1 aGallego, Asunción1 aArnau, Vicente1 aMedina, Ignacio1 aDopazo, Joaquin  uhttp://www.biomedcentral.com/1471-2105/17/107