02075nas a2200205   4500008004100000245012600041210006900167300001100236490000700247520124100254653010501495653005601600100001401656700002301670700002101693700001901714700001501733700001501748856010601763       2005                        eng d00aPupasView: a visual tool for selecting suitable SNPs, with putative pathological effect in genes, for genotyping purposes0 aPupasView a visual tool for selecting suitable SNPs with putativ  aW501-50 v333 aWe have developed a web tool, PupasView, for the selection of single nucleotide polymorphisms (SNPs) with potential phenotypic effect. PupasView constitutes an interactive environment in which functional information and population frequency data can be used as sequential filters over linkage disequilibrium parameters to obtain a final list of SNPs optimal for genotyping purposes. PupasView is the first resource that integrates phenotypic effects caused by SNPs at both the translational and the transcriptional level. PupasView retrieves SNPs that could affect conserved regions that the cellular machinery uses for the correct processing of genes (intron/exon boundaries or exonic splicing enhancers), predicted transcription factor binding sites and changes in amino acids in the proteins for which a putative pathological effect is calculated. The program uses the mapping of SNPs in the genome provided by Ensembl. PupasView will be of much help in studies of multifactorial disorders, where the use of functional SNPs will increase the sensitivity of the identification of the genes responsible for the disease. The PupasView web interface is accessible through http://pupasview.ochoa.fib.es and through http://www.pupasnp.org.10aComputer Graphics Genes *Genetic Predisposition to Disease Genotype Internet Phenotype *Polymorphism10aSingle Nucleotide *Software User-Computer Interface1 aConde, L.1 aVaquerizas, J., M.1 aFerrer-Costa, C.1 ade la Cruz, X.1 aOrozco, M.1 aDopazo, J.  uhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15980522