01413nas a2200181   4500008004100000245005600041210005500097300001100152490000700163520072100170653007700891653008700968100001701055700001501072700002101087700001701108856010601125       2005                        eng d00aHCAD, closing the gap between breakpoints and genes0 aHCAD closing the gap between breakpoints and genes  aD511-30 v333 aRecurrent chromosome aberrations are an important resource when associating human pathologies to specific genes. However, for technical reasons a large number of chromosome breakpoints are defined only at the level of cytobands and many of the genes involved remain unidentified. We developed a web-based information system that mines the scientific literature and generates textual and comprehensive information on all human breakpoints. We show that the statistical analysis of this textual information and its combination with genomic data can identify genes directly involved in DNA rearrangements. The Human Chromosome Aberration Database (HCAD) is publicly accessible at http://www.pdg.cnb.uam.es/UniPub/HCAD/.10a*Chromosome Breakage Chromosome Disorders/diagnosis/*genetics *Databases10aGenetic Genes *Genetic Predisposition to Disease Humans PubMed Systems Integration1 aHoffmann, R.1 aDopazo, J.1 aCigudosa, J., C.1 aValencia, A.  uhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15608250