01187nas a2200145   4500008004100000245013100041210006900172300000800241490000600249520062400255100001900879700001300898700002400911856010600935       2008                        eng d00aEvolutionary potentials: structure specific knowledge-based potentials exploiting the evolutionary record of sequence homologs0 aEvolutionary potentials structure specific knowledgebased potent  aR680 v93 aABSTRACT: We introduce a new type of knowledge-based potentials for protein structure prediction, called ’evolutionary potentials’, which are derived using a single experimental protein structure and all three-dimensional models of its homologous sequences. The new potentials have been benchmarked against other knowledge-based potentials, resulting in a significant increase in accuracy for model assessment. In contrast to standard knowledge-based potentials, we propose that evolutionary potentials capture key determinants of thermodynamic stability and specific sequence constraints required for fast folding.1 aPanjkovich, A.1 aMelo, F.1 aMarti-Renom, M., A.  uhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18397517