02102nas a2200217   4500008004100000245007500041210006900116300001200185490000700197520140300204653001001607653002901617100001601646700002301662700002401685700001401709700001501723700002501738700001501763856010601778       2004                        eng d00aNew challenges in gene expression data analysis and the extended GEPAS0 aNew challenges in gene expression data analysis and the extended  aW485-910 v323 a<p>Since the first papers published in the late nineties, including, for the first time, a comprehensive analysis of microarray data, the number of questions that have been addressed through this technique have both increased and diversified. Initially, interest focussed on genes coexpressing across sets of experimental conditions, implying, essentially, the use of clustering techniques. Recently, however, interest has focussed more on finding genes differentially expressed among distinct classes of experiments, or correlated to diverse clinical outcomes, as well as in building predictors. In addition to this, the availability of accurate genomic data and the recent implementation of CGH arrays has made mapping expression and genomic data on the chromosomes possible. There is also a clear demand for methods that allow the automatic transfer of biological information to the results of microarray experiments. Different initiatives, such as the Gene Ontology (GO) consortium, pathways databases, protein functional motifs, etc., provide curated annotations for genes. Whereas many resources on the web focus mainly on clustering methods, GEPAS has evolved to cope with the aforementioned new challenges that have recently arisen in the field of microarray data analysis. The web-based pipeline for microarray gene expression data, GEPAS, is available at http://gepas.bioinfo.cnio.es.</p>10agepas10amicroarray data analysis1 aHerrero, J.1 aVaquerizas, J., M.1 aAl-Shahrour, Fatima1 aConde, L.1 aMateos, A.1 aDiaz-Uriarte, J., S.1 aDopazo, J.  uhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15215434