@article {21919703,
	title = {Assessing Differential Expression Measurements by Highly Parallel Pyrosequencing and DNA Microarrays: A Comparative Study.},
	journal = {Omics : a journal of integrative biology},
	year = {2013},
	month = {2011 Sep 15},
	abstract = {<p>Abstract To explore the feasibility of pyrosequencing for quantitative differential gene expression analysis we have performed a comparative study of the results of the sequencing experiments to those obtained by a conventional DNA microarray platform. A conclusion from our analysis is that, over a threshold of 35 normalized reads per gene, the measurements of gene expression display a good correlation with the references. The observed concordance between pyrosequencing and DNA microarray platforms beyond the threshold was of 0.8, measured as a Pearson{\textquoteright}s correlation coefficient. In differential gene expression the initial aim is the quantification the differences among transcripts when comparing experimental conditions. Thus, even in a scenario of low coverage the concordance in the measurements is quite acceptable. On the other hand, the comparatively longer read size obtained by pyrosequencing allows detecting unconventional splicing forms.</p>},
	doi = {10.1089/omi.2011.0065},
	url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545353/},
	author = {Ari{\~n}o, Joaqu{\'\i}n and Casamayor, Antonio and P{\'e}rez, Juli{\'a}n Perez and Pedrola, Laia and Alvarez-Tejado, Miguel and Marb{\`a}, Martina and Santoyo, Javier and Joaqu{\'\i}n Dopazo}
}
