@article {15297397,
	title = {Expression profiling of T-cell lymphomas differentiates peripheral and lymphoblastic lymphomas and defines survival related genes.},
	journal = {Clinical cancer research : an official journal of the American Association for Cancer Research},
	volume = {10},
	year = {2004},
	month = {2004 Aug 1},
	pages = {4971-82},
	abstract = {<p>PURPOSE: T-Cell lymphomas constitute heterogeneous and aggressive tumors in which pathogenic alterations remain largely unknown. Expression profiling has demonstrated to be a useful tool for molecular classification of tumors. EXPERIMENTAL DESIGN: Using DNA microarrays (CNIO-OncoChip) containing 6386 cancer-related genes, we established the expression profiling of T-cell lymphomas and compared them to normal lymphocytes and lymph nodes. RESULTS: We found significant differences between the peripheral and lymphoblastic T-cell lymphomas, which include a deregulation of nuclear factor-kappaB signaling pathway. We also identify differentially expressed genes between peripheral T-cell lymphoma tumors and normal T lymphocytes or reactive lymph nodes, which could represent candidate tumor markers of these lymphomas. Additionally, a close relationship between genes associated to survival and those that differentiate among the stages of disease and responses to therapy was found. CONCLUSIONS: Our results reflect the value of gene expression profiling to gain insight about the molecular alterations involved in the pathogenesis of T-cell lymphomas.</p>},
	url = {http://clincancerres.aacrjournals.org/content/10/15/4971.long},
	author = {Martinez-Delgado, Beatriz and Mel{\'e}ndez, Barbara and Cuadros, Marta and Alvarez, Javier and Castrillo, Jose Maria and Ruiz De La Parte, Ana and Mollejo, Manuela and Bellas, Carmen and Diaz, Ramon and Lombard{\'\i}a, Luis and Fatima Al-Shahrour and Dom{\'\i}nguez, Orlando and Cascon, Alberto and Robledo, Mercedes and Rivas, Carmen and Benitez, Javier}
}
