@article {16204094,
	title = {Lineage-specific gene loss following mitochondrial endosymbiosis and its potential for function prediction in eukaryotes},
	journal = {Bioinformatics},
	volume = {21 Suppl 2},
	year = {2005},
	note = {Gabaldon, Toni Huynen, Martijn A Research Support, Non-U.S. Gov{\textquoteright}t England Bioinformatics (Oxford, England) Bioinformatics. 2005 Sep 1;21 Suppl 2:ii144-50.},
	pages = {ii144-50},
	abstract = {MOTIVATION: The endosymbiotic origin of mitochondria has resulted in a massive horizontal transfer of genetic material from an alpha-proteobacterium to the early eukaryotes. Using large-scale phylogenetic analysis we have previously identified 630 orthologous groups of proteins derived from this event. Here we show that this proto-mitochondrial protein set has undergone extensive lineage-specific gene loss in the eukaryotes, with an average of three losses per orthologous group in a phylogeny of nine species. This gene loss has resulted in a high variability of the alphaproteobacterial-derived gene content of present-day eukaryotic genomes that might reflect functional adaptation to different environments. Proteins functioning in the same biochemical pathway tend to have a similar history of gene loss events, and we use this property to predict functional interactions among proteins in our set.},
	keywords = {Animals Chromosome Mapping/*methods DNA, Mitochondrial/*genetics *Evolution, Molecular *Gene Deletion Genetic Variation/genetics Humans Linkage Disequilibrium/*genetics Mitochondrial Proteins/*genetics Sequence Homology, Nucleic Acid Species Specificity Symbiosis/*genetics},
	url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve\&db=PubMed\&dopt=Citation\&list_uids=16204094},
	author = {Gabald{\'o}n, T. and M. A. Huynen}
}
