%0 Journal Article %J Genome Biol %D 2008 %T Evolutionary potentials: structure specific knowledge-based potentials exploiting the evolutionary record of sequence homologs %A Panjkovich, A. %A Melo, F. %A M. A. Marti-Renom %X ABSTRACT: We introduce a new type of knowledge-based potentials for protein structure prediction, called ’evolutionary potentials’, which are derived using a single experimental protein structure and all three-dimensional models of its homologous sequences. The new potentials have been benchmarked against other knowledge-based potentials, resulting in a significant increase in accuracy for model assessment. In contrast to standard knowledge-based potentials, we propose that evolutionary potentials capture key determinants of thermodynamic stability and specific sequence constraints required for fast folding. %B Genome Biol %V 9 %P R68 %G eng %U http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18397517