02520nas a2200445 4500008004100000022001400041245009400055210006900149260000900218300001200227490000600239520119500245653001201440653001501452653001901467653001601486653002701502653002101529653001101550653002901561653001601590653001001606653003001616653001501646653001301661653001401674653001201688653001501700100001801715700002801733700003301761700002001794700002901814700001801843700002401861700002001885700002301905700002201928856012401950 2014 eng d a1932-620300aPermanent cardiac sarcomere changes in a rabbit model of intrauterine growth restriction.0 aPermanent cardiac sarcomere changes in a rabbit model of intraut c2014 ae1130670 v93 a
BACKGROUND: Intrauterine growth restriction (IUGR) induces fetal cardiac remodelling and dysfunction, which persists postnatally and may explain the link between low birth weight and increased cardiovascular mortality in adulthood. However, the cellular and molecular bases for these changes are still not well understood. We tested the hypothesis that IUGR is associated with structural and functional gene expression changes in the fetal sarcomere cytoarchitecture, which remain present in adulthood.
METHODS AND RESULTS: IUGR was induced in New Zealand pregnant rabbits by selective ligation of the utero-placental vessels. Fetal echocardiography demonstrated more globular hearts and signs of cardiac dysfunction in IUGR. Second harmonic generation microscopy (SHGM) showed shorter sarcomere length and shorter A-band and thick-thin filament interaction lengths, that were already present in utero and persisted at 70 postnatal days (adulthood). Sarcomeric M-band (GO: 0031430) functional term was over-represented in IUGR fetal hearts.
CONCLUSION: The results suggest that IUGR induces cardiac dysfunction and permanent changes on the sarcomere.
10aAnimals10abiomarkers10aBlood Pressure10aBody Weight10aDisease Models, Animal10aEchocardiography10aFemale10aFetal Growth Retardation10aFetal Heart10aFetus10aGene Expression Profiling10aOrgan Size10aPlacenta10aPregnancy10aRabbits10aSarcomeres1 aTorre, Iratxe1 aGonzález-Tendero, Anna1 aGarcía-Cañadilla, Patricia1 aCrispi, Fátima1 aGarcia-Garcia, Francisco1 aBijnens, Bart1 aIruretagoyena, Igor1 aDopazo, Joaquin1 aAmat-Roldán, Ivan1 aGratacós, Eduard uhttps://www.clinbioinfosspa.es/content/permanent-cardiac-sarcomere-changes-rabbit-model-intrauterine-growth-restriction