01461nas a2200253 4500008004100000245009300041210006900134260000900203300000700212490000700219520063100226100002300857700001500880700001900895700002300914700002800937700001500965700001700980700002100997700002401018700002001042700002001062856012501082 2011 eng d00aRecent human evolution has shaped geographical differences in susceptibility to disease.0 aRecent human evolution has shaped geographical differences in su c2011 a550 v123 a
Searching for associations between genetic variants and complex diseases has been a very active area of research for over two decades. More than 51,000 potential associations have been studied and published, a figure that keeps increasing, especially with the recent explosion of array-based Genome-Wide Association Studies. Even if the number of true associations described so far is high, many of the putative risk variants detected so far have failed to be consistently replicated and are widely considered false positives. Here, we focus on the world-wide patterns of replicability of published association studies.
1 aMarigorta, Urko, M1 aLao, Oscar1 aCasals, Ferran1 aCalafell, Francesc1 aMorcillo-Suarez, Carlos1 aFaria, Rui1 aBosch, Elena1 aSerra, François1 aBertranpetit, Jaume1 aDopazo, Hernán1 aNavarro, Arcadi uhttps://www.clinbioinfosspa.es/content/recent-human-evolution-has-shaped-geographical-differences-susceptibility-disease