SNOW, a web-based tool for the statistical analysis of protein-protein interaction networks.

TitleSNOW, a web-based tool for the statistical analysis of protein-protein interaction networks.
Publication TypeJournal Article
Year of Publication2009
AuthorsMinguez, P, Götz, S, Montaner, D, Al-Shahrour, F, Dopazo, J
JournalNucleic Acids Res
Volume37
IssueWeb Server issue
PaginationW109-14
Date Published2009 Jul
ISSN1362-4962
KeywordsComputer Graphics; Data Interpretation, Statistical; Databases, Protein; Humans; Internet; Protein Interaction Mapping; Software
Abstract

Understanding the structure and the dynamics of the complex intercellular network of interactions that contributes to the structure and function of a living cell is one of the main challenges of today's biology. SNOW inputs a collection of protein (or gene) identifiers and, by using the interactome as scaffold, draws the connections among them, calculates several relevant network parameters and, as a novelty among the rest of tools of its class, it estimates their statistical significance. The parameters calculated for each node are: connectivity, betweenness and clustering coefficient. It also calculates the number of components, number of bicomponents and articulation points. An interactive network viewer is also available to explore the resulting network. SNOW is available at http://snow.bioinfo.cipf.es.

DOI10.1093/nar/gkp402
Alternate JournalNucleic Acids Res
PubMed ID19454602
PubMed Central IDPMC2703972